Mood and the Microbiome: How Gut Health Affects Emotions

Dec 9, 2025

Nutrition

TL;DR 

Our gut bacteria influence far more than digestion,  they play a significant role in emotional health. A balanced microbiome helps regulate serotonin and dopamine, supporting calmness, focus, and emotional stability. When the gut becomes imbalanced, changes in mood, stress levels, and mental clarity often follow. 


Introduction 

Feeling low, anxious, or emotionally off? The cause might not be solely in our mind, it may begin in our gut. 

Researchers have discovered that people experiencing depression often have different compositions of gut bacteria compared to people without depression (Cheung et al., 2019). This means the microbes living in your digestive tract might be influencing our emotional world more than we realize. 

Understanding how our microbiome affects mood is an empowering step toward caring for both our mental and physical well-being. 


What Is the Gut Microbiome? 

The gut microbiome refers to the trillions of bacteria, fungi, and microorganisms living in our digestive system. These microbes are deeply involved in: 

  • Breaking down food 

  • Producing vitamins 

  • Regulating inflammation 

  • Maintaining metabolism 

A balanced microbiome produces short-chain fatty acids (SCFAs) , powerful compounds that: 

  • Improve immune function 

  • Reduce inflammation 

  • Support hormone balance 

  • Enhance communication between the gut and brain (Sandhu et al., 2017) 

When the microbiome becomes imbalanced, these beneficial processes weaken, influencing our overall mood and energy. 


The Gut’s Role in Mood 

Our gut is often called the “second brain” and for good reason. It produces and regulates many of the same neurotransmitters used in emotional processing. 

Key Mood-Regulating Neurotransmitters Made in the Gut 

  1. Serotonin 
    Helps regulate mood, sleep, appetite, and emotional stability. 

  2. Dopamine 
    Influences motivation, pleasure, and reward systems. 

  3. GABA 
    Calms the nervous system and reduces anxious activation. 

When gut bacteria are imbalanced (a state called dysbiosis), communication between the gut and brain becomes disrupted. Research shows this can contribute to: 

  • Increased anxiety 

  • Irritability 

  • Depressive symptoms 

  • Stress sensitivity 
    (Strandwitz, 2018; Liu et al., 2016) 


How to Support Gut-Driven Mood Health

Small lifestyle changes can support microbial balance and improve emotional wellness. 

1. Eat More Plants and Fiber 

Fiber feeds healthy gut bacteria, which then produce SCFAs,  compounds known to support mood and reduce inflammation. 

2. Add Fermented Foods 

Foods like yogurt, kefir, kimchi, sauerkraut, and miso provide probiotics that naturally help rebalance your gut flora. 

3. Reduce Stress 

Chronic stress harms gut bacteria. Mindfulness, grounding, and therapy can all help support a regulated nervous system which in turn supports a healthier microbiome. 

4. Prioritize Sleep 

Sleep disruptions negatively affect gut function and emotional resilience. 

5. Limit Processed Foods and Excess Sugar 

Heavily processed foods can decrease microbial diversity, and lower diversity is linked with poorer mood outcomes. 

 

How Wild Hope Counseling & Coaching Can Help 

At Wild Hope, we understand that emotional and physical health are deeply interconnected including the relationship between gut function and mental well-being. 

Our holistic, trauma-informed approach supports your mood and nervous system through: 

  • Mindfulness and grounding practices 

  • Nervous system regulation techniques 

  • Support for stress, anxiety, and emotional overwhelm 

  • Exploration of how trauma impacts both the brain and body 

  • Psychoeducation about the gut-brain connection 

  • Compassionate guidance for lifestyle changes tied to mental health 

We help you restore balance to both your emotional world and your physical system, creating a foundation for calm, clarity, and resilience. 

📩 Reach out: contact@wildhopecc.com 


FAQ 

1. Can improving my gut health really help my mood? 

Yes. Research shows strong links between gut balance and emotional well-being, particularly for anxiety and depression. 

2. What harms gut health the most? 

Common disruptors include: 

  • Chronic stress 

  • Processed foods 

  • Lack of sleep 

  • Excessive alcohol use 

  • Long-term antibiotic use 

  • Low fiber intake 

3. What are SCFAs? 

Short-chain fatty acids (SCFAs) are beneficial compounds created when gut bacteria digest fiber. They help: 

  • Support brain function 

  • Reduce inflammation 

  • Strengthen the intestinal lining 

  • Promote emotional regulation 

4. Do probiotics actually help? 

For many people, yes — but not all probiotics are equal. Diversity of plant foods, fermented foods, and stress reduction often create more sustainable improvements than supplements alone. 


Summary 

Our gut plays a much larger role in our emotional life than we might expect. When our microbiome is healthy and diverse, it supports the production of neurotransmitters that help us feel grounded, calm, and emotionally resilient. By caring for both our gut and our mental health — through food, stress reduction, sleep, and therapy — we nurture a foundation for long-term well-being. 


References 

Cheung, S. G., Goldenthal, A. R., Uhlemann, A. C., Mann, J. J., Miller, J. M., & Sublette, M. E. (2019). Systematic review of gut microbiota and major depression. Journal of Affective Disorders, 245, 1–15. https://pubmed.ncbi.nlm.nih.gov/30804820/ 

Liu, R. T., Walsh, R. F., & Sheehan, A. E. (2016). Prebiotics and probiotics for depression and anxiety: A systematic review of controlled clinical trials. Neuroscience & Biobehavioral Reviews, 74, 1–17. https://pubmed.ncbi.nlm.nih.gov/31004628/ 

Sandhu, K. V., Sherwin, E., Schellekens, H., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017). Feeding the microbiota-gut-brain axis: Diet, microbiome, and neuropsychiatry. Current Opinion in Neurobiology, 44, 103–112. https://pubmed.ncbi.nlm.nih.gov/27832936/ 

Strandwitz, P. (2018). Neurotransmitter modulation by the gut microbiota. Brain Research, 1693, 128–133. https://pubmed.ncbi.nlm.nih.gov/29903615/ 

Wild Hope Counseling and Coaching is a virtual mental health therapy practice serving the residents of Michigan, USA.

Phone: 810-545-7773 | Email: contact@wildhopecc.com

We welcome all, including sexual orientation, age, race, disability, ethnicity/national origin, gender identity, and religious/spiritual affiliation.

Wild Hope Counseling and Coaching is a virtual mental health therapy practice serving the residents of Michigan, USA.

Phone: 810-545-7773 | Email: contact@wildhopecc.com

We welcome all, including sexual orientation, age, race, disability, ethnicity/national origin, gender identity, and religious/spiritual affiliation.

Wild Hope Counseling and Coaching is a virtual mental health

therapy practice serving the residents of Michigan, USA.

Phone: 810-545-7773 | Email: contact@wildhopecc.com